Prof. Dr. Julio Vera
During the last fifteen years, I have worked in the development of computational methods for data-driven mathematical modelling of biochemical pathways and networks relevant to human diseases, in particular cancer.
I am currently integrating biomedical knowledge contained in databases, computational tools and high-throughput data into mathematical models of miRNA-regulated networks. We are applying this method to understand the role of miRNAs in the interaction between tumors and the immune system.
See my ResearchGate profile
During the last fifteen years, I have worked in the development of computational methods for data-driven mathematical modelling of biochemical pathways and networks relevant to human diseases, in particular cancer.
I am currently integrating biomedical knowledge contained in databases, computational tools and high-throughput data into mathematical models of miRNA-regulated networks. We are applying this method to understand the role of miRNAs in the interaction between tumors and the immune system.
See my ResearchGate profile
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Dr. Xin Lai
works in the reconstruction and modelling of miRNA networks in cancer and inflammation See my ResearchGate profile |
Dr. Florian Dreyer
My current research focuses on the investigation of resistance mechanisms to anti-cancer immunotherapy based on tumor cell type specific molecular networks. In particular, I am identifying molecular core networks in therapy-resistant tumors in order to detect molecular factors whose co-targeting along with anti-cancer immunotherapy can improve treatment.
In addition, I am investigating potential therapeutic effects of antibodies, generated using circulating EVs from tumor patients and cell culture supernatants, in close collaboration with the Helmholtz Zentrum Munich. These research projects include the supervision of a doctoral student and collaborations with several other research groups. Furthermore, I investigated the role of circulating EVs in melanoma patients in my PhD project.
My current research focuses on the investigation of resistance mechanisms to anti-cancer immunotherapy based on tumor cell type specific molecular networks. In particular, I am identifying molecular core networks in therapy-resistant tumors in order to detect molecular factors whose co-targeting along with anti-cancer immunotherapy can improve treatment.
In addition, I am investigating potential therapeutic effects of antibodies, generated using circulating EVs from tumor patients and cell culture supernatants, in close collaboration with the Helmholtz Zentrum Munich. These research projects include the supervision of a doctoral student and collaborations with several other research groups. Furthermore, I investigated the role of circulating EVs in melanoma patients in my PhD project.
M.Sc. Martin Eberhardt. He develops web-based software tools for the reconstruction of miRNA networks
M.Sc. Christopher Lischer. He applies machine learning algorithms to tumor epitope detection
M.Sc. Jimmy Retzlaff. He contructs multi-level models of tumor-immunity interaction in melanoma immunotherapy
M.Sc. Jyoti Kant Choudhary. He applies network biology approaches to glaucoma pathophisiology
B.Sc. Chistine Keller. She models dendritic cell-based anticancer therapy
B.Sc. Adrian Weich. He builds and analyze networks lniked to cancer and autoimmunity
M.Sc. Christopher Lischer. He applies machine learning algorithms to tumor epitope detection
M.Sc. Jimmy Retzlaff. He contructs multi-level models of tumor-immunity interaction in melanoma immunotherapy
M.Sc. Jyoti Kant Choudhary. He applies network biology approaches to glaucoma pathophisiology
B.Sc. Chistine Keller. She models dendritic cell-based anticancer therapy
B.Sc. Adrian Weich. He builds and analyze networks lniked to cancer and autoimmunity
PhD and MD theses
Tristan Wetzel (since 2017). “Reconstruction of a network accounting for the tumour-immunity interaction in aggressive melanoma”
Martina Cantone (2016-2020). “Computational Methods for Analysis and Simulations of HighThroughput Scale Regulatory Networks in Neurobiology”.
Tanushree Jaitly. (Mar 2016 - Mar 2020). “In-Silico Design of an Anti-Cancer Vaccine”
Master and Bachelor theses
Hative Demiran (Since Sep 2020). AU Erlangen-Nürnberg. Master's thesis on network biology applied to autoimmunity
David Chambers (since Apr 2020). FAU Erlangen-Nürnberg. Master's thesis on network biology applied to macrophages in autoimmunity
Jimmy Retzlaff (Jun-Oct 2019). FAU Erlangen-Nürnberg. Master's thesis on computer modelling to the understanding of tumor-immunity interaction.
Adrian Weich (Apr-Sep 2020). FAU Erlangen-Nürnberg. Bachelor thesis on systems biology applied to uveal melanoma
Dagmar Ilzhöfer (Apr-Sep 2020). FAU Erlangen-Nürnberg. Bachelor thesis on on network biology applied to microglia
Chistine Keller (2019). Bachelor Thesis on computer modelling dendritic cell-based anticancer therapy. Now Master student at FAU Erlangen-Nürnberg
Christina Blume (Mar - Oct 2019). Master's thesis on network biology methods to the differentiation of astrocytes. Now in DKFZ Heidelberg, Germany
Philipp Junk (Aug 2017 - May 2018). FAU Erlangen-Nürnberg. Master's thesis on network propagation. Now in PhD student ad UD Dublin, Ireland
Philipp Hornauer (May - Nov 2017). FAU Erlangen-Nürnberg. Master's thesis on modeling multiple sclerosis. Now PhD Student at ETH ZUrich, Switzerland
Tobias Pfaller (Aug 2016 - 2017). TH Nürnberg Georg Simon Ohm. Bachelor's thesis on lung infection modelling. Now Master student at FAU Erlangen-Nürnberg
Fitsumbirhan Mehari (Oct 2015 - Ap 2016) . Master thesis on dendritic cells network biology. Now PhD student at LMU Munich, Germany
Mohammad Naveez (Sep - Dec 2016). University of Riga, Latvia. Master's thesis on colorectal cancer network reconstruction
Martina Cantone (May - Sep 2014). University of Pavia, Italy. Master's thesis on reconstruction of a melanoma progression network. Now Postdoc in TUM, Germany
David Chambers (since Apr 2020). FAU Erlangen-Nürnberg. Master's thesis on network biology applied to macrophages in autoimmunity
Jimmy Retzlaff (Jun-Oct 2019). FAU Erlangen-Nürnberg. Master's thesis on computer modelling to the understanding of tumor-immunity interaction.
Adrian Weich (Apr-Sep 2020). FAU Erlangen-Nürnberg. Bachelor thesis on systems biology applied to uveal melanoma
Dagmar Ilzhöfer (Apr-Sep 2020). FAU Erlangen-Nürnberg. Bachelor thesis on on network biology applied to microglia
Chistine Keller (2019). Bachelor Thesis on computer modelling dendritic cell-based anticancer therapy. Now Master student at FAU Erlangen-Nürnberg
Christina Blume (Mar - Oct 2019). Master's thesis on network biology methods to the differentiation of astrocytes. Now in DKFZ Heidelberg, Germany
Philipp Junk (Aug 2017 - May 2018). FAU Erlangen-Nürnberg. Master's thesis on network propagation. Now in PhD student ad UD Dublin, Ireland
Philipp Hornauer (May - Nov 2017). FAU Erlangen-Nürnberg. Master's thesis on modeling multiple sclerosis. Now PhD Student at ETH ZUrich, Switzerland
Tobias Pfaller (Aug 2016 - 2017). TH Nürnberg Georg Simon Ohm. Bachelor's thesis on lung infection modelling. Now Master student at FAU Erlangen-Nürnberg
Fitsumbirhan Mehari (Oct 2015 - Ap 2016) . Master thesis on dendritic cells network biology. Now PhD student at LMU Munich, Germany
Mohammad Naveez (Sep - Dec 2016). University of Riga, Latvia. Master's thesis on colorectal cancer network reconstruction
Martina Cantone (May - Sep 2014). University of Pavia, Italy. Master's thesis on reconstruction of a melanoma progression network. Now Postdoc in TUM, Germany
Associate Members
Prof. Dr. Svetoslav Nikolov. Bulgarian Academy of Sciences, Sofia, Bulgaria.
He collaborates with us in chaos theory in tumor and immune response dynamics. See our paper on this topic
Prof. Dr. Guido Santos Rosales. Dept. of Biochemistry. University of La Laguna, Spain.
He collaborates with us in the modelling of bacterial lung infection. See our paper on this topic
Visitors
Jessica Kalla (Nov 2019- Jan 2020). Internship on network reconstruction and programming
Luise Marie Zeckey (May - Jul 2019). FAU Erlangen-Nürnberg. Internship on network reconstruction and programming
Adrian Weich (Mar 2019). FAU Erlangen-Nürnberg. Internship on machine learning
Richard Matschke (Mar 2018). Universität Göttingen. Internship on network reconstruction
Ahammed Sidheek (Jun 2017 - May 2018). FAU Erlangen-Nürnberg. Assistant in agent-based modelling of lung infection
Franziska Karl (Mar - Apr 2016). FAU Erlangen-Nürnberg. Internship on cytokine networks in lung infection
Ralitsa Langova (Apr - Sep 2016). Heidelberg University. Internship in data analysis and network reconstruction
Guido Santos Rosales (Jul - Dec 2015). University of La Laguna, Spain
Dr. Eva Balsa Canto (Jun - Jul 2015). Spanish Research Council, Vigo, Spain
Jessica Kalla (Nov 2019- Jan 2020). Internship on network reconstruction and programming
Luise Marie Zeckey (May - Jul 2019). FAU Erlangen-Nürnberg. Internship on network reconstruction and programming
Adrian Weich (Mar 2019). FAU Erlangen-Nürnberg. Internship on machine learning
Richard Matschke (Mar 2018). Universität Göttingen. Internship on network reconstruction
Ahammed Sidheek (Jun 2017 - May 2018). FAU Erlangen-Nürnberg. Assistant in agent-based modelling of lung infection
Franziska Karl (Mar - Apr 2016). FAU Erlangen-Nürnberg. Internship on cytokine networks in lung infection
Ralitsa Langova (Apr - Sep 2016). Heidelberg University. Internship in data analysis and network reconstruction
Guido Santos Rosales (Jul - Dec 2015). University of La Laguna, Spain
Dr. Eva Balsa Canto (Jun - Jul 2015). Spanish Research Council, Vigo, Spain
Former Members
M.Sc. Tanushree Jaitly. Joined Applied StemCell Inc., San Francisco Bay, USA.
Prof. Dr. Guido Santos Rosales. Joined ULL at La Laguna, Spain as assistant professor.
M.Sc. Martina Cantone. Joined TU Munich, Germany as post.doc.
Dr. Shishir Gupta. Joined JMU Würzburg, Germany as Post-Doc.
M.Sc. Fitsumbirhan Mehari. Joined LMU Munich, Germany as PhD student.
Dr. Pia Wentker. Joined a Biotech company in Northrhine-Westphalia, Germany.
Dr. Sushmita Paul. Joined the Indian Institute of Technology in Jodhpur, India.
Dr. Namrata Tomar. Joined Medical College of Wisconsin, Milwaukee, USA as Post-Doc.
Dr. Karin Schleinkofer.
M.Sc. Sayed Hasnine. Joined PennState, USA as PhD student.
Prof. Dr. Guido Santos Rosales. Joined ULL at La Laguna, Spain as assistant professor.
M.Sc. Martina Cantone. Joined TU Munich, Germany as post.doc.
Dr. Shishir Gupta. Joined JMU Würzburg, Germany as Post-Doc.
M.Sc. Fitsumbirhan Mehari. Joined LMU Munich, Germany as PhD student.
Dr. Pia Wentker. Joined a Biotech company in Northrhine-Westphalia, Germany.
Dr. Sushmita Paul. Joined the Indian Institute of Technology in Jodhpur, India.
Dr. Namrata Tomar. Joined Medical College of Wisconsin, Milwaukee, USA as Post-Doc.
Dr. Karin Schleinkofer.
M.Sc. Sayed Hasnine. Joined PennState, USA as PhD student.
